The 9th Annual CCF Symposium was held on June 4, 2025.

In the next few weeks, this page will have the recorded talks given throughout the day. Check back often.

9th Annual CCF Research Symposium Presentation List
June 4, 2025

Session I : Leukemia and other Blood Cancers
“Update and Challenges in Cell-Based Therapies in Leukemia”
Sara Silbert, M.D., M.H.Sc., National Cancer
Institute, Center for Cancer Research (NCI, CCR)
Holly Barton, Leukemia fighter and mother Lauren
“Chimeric cytokine receptors increase NK-cell functionality against AML”
Natalie Holl, Johns Hopkins University
“Disparities between bone marrow B-cell aplasia and minimal residual
disease in pediatric and AYA B-ALL after CAR T-cell therapy”
Chelsea O’Koren, M.D., NCI, CCR
“miR-21 Regulates T-Cell Alloreactivity and GVHD Severity in Experimental Allo-HCT”
Margarita Dionysiou, M.D., Johns Hopkins University
The Jeffrey A. Toretsky Honorary Keynote Panel: “AI: Potential and Challenges for Pediatric Oncology”
Taylor Sundby, M.D., NCI, CCR, POB, Presenter and Moderator
Marius Linguraru, Ph.D., Children’s National, Panelist
David Milewski, Ph.D., NCI, CCR, Genetics Branch, Panelist
Joe C. Murray, M.D. Ph.D., Johns Hopkins University, Panelist
Session II: Challenges and scientific advances in pediatric and AYA oncology
“AYA Clinical Trials and Care Challenges”
Heather Symons, M.D. M.H.S., Johns Hopkins University
Bella Teta, Brain Tumor Survivor
Introduction by Brian Rood, M.D., Children’s National
“A Tale of States: Decoding the Role of MYCN Amplification in
ADRN-MES Plasticity”
Stefano Di Giulio, Ph.D., NCI, CCR
“Reprogramming Tumor-Associated Macrophages to Enhance CAR T Cell Therapy in Group 3 Medulloblastoma”
Serge Yaacoub, M.D., Children’s National
“Developmental states determine intrinsic resistance to immunotherapy in pediatric rhabdomyosarcoma”
Maya Groff, NCI, CCR

About the CCF Symposium

Launched in 2016, CCF annually hosts the one-day CCF Research Symposium. The brainchild of CCF’s Scientific Advisory Board Chair Emeritus Jeffrey Toretsky, M.D., the CCF Research Symposium puts forth the belief that small local research dialogue will lead to substantial research collaboration.

Regional experts (including nurses, doctors, therapists, etc.), advocates, and trainees have shared research and continue to advance the treatment of childhood cancer. The CCF Research Symposium is also unique in its inclusion of presentations from cancer fighters and their families, infusing the day with “heart” by sharing their cancer journeys.

The CCF Symposium is made possible with generous support from The Kahlert Foundation.

Past Symposia